Lung cancer Research Paper Example | Topics and Well Written Essays - 2000 words

Lung cancer - Research Paper Example In the United States, about 203,536 people are found to suffer from the disease regardless of sex with death of over 157, 000 victims in 2010 (www.cdc.gov/cancer/lung). Other countries have showed the same trend. In Europe, many countries showed high rate of deaths with Hungary in the top list having deaths that reached over a hundred victims a day. In Canada, lung cancer accounts for 30% death with cases of women on the rise. Far East Asia is not spared from the disease. Philippines alone have 43 daily cases of deaths. Taiwan and Japan share the same sentiment regarding the disease. China also has continual increase in numbers who die from the disease (Pastorino, 102). This scenario provides a picture that lung cancer is prevalent worldwide regardless of sex. Limiting the incidences of the lung cancer involves understanding the pathophysiology, causes, signs and symptoms, and diagnosis to be able to treat the disease at an earlier stage and to prevent high prevalence of its occurren ces. Pathophysiology The normal lung cell consist of two layers namely the columnar cells and basal cells. The columnar that contains mucus and covered with cilia makes up the surface layer. Basal cell which is the second layer contains the nuclei and basement membrane which in turn composes the glands, blood, blood vessels and lymphatic vessels. The initial response to a carcinogenic agent occurs in the tracheobronchial epithelium within the basal cells. Number of cells increase as it is triggered with the inhalation of any carcinogenic agents and referred to as carcinomas. This happens because oncogenes which make the body susceptible to cancer are activated. When a carcinogen enters the body, it binds with the DNA of the lung cells causing changes and differentiation of the cell. The structures of the cells are damaged which may cause abnormal growth. As the cell division continues to occur, the damaged DNA is also passed to the daughter cells and undergoes further mutations. Cel l growth becomes unstable and genetic changes accumulate. The pulmoepithelium in turn undergoes malignant transformation from normal epithelium to invasive carcinoma (Day, et al, p 558). Among the lung cancer type, adenocarcinoma is the most prevalent. However, when cancer cells metastasize, the tracheal and broncheal lymph nodes are the earliest to show signs of the spread to distant lymph nodes, organs, kidneys and brain. On the other hand, broncheoalveolar type is usually slow in nature than other types. Pleural effusion results as an effect of direct involvement of the pleura, obstruction of mediastinal lymphatics, throracic duct, pulmonary lymphatics, and atelectasis with pneumonitis and pulmonary embolus. Causes Lung cancer is believed to have many causes. It could be provoked with many carcinogens like tobacco smoke, radiations and viral infections. Although the disease is known to be a familial tendency, the risk depends with the exposure to carcinogenic risk factors. Almost all types of lung cancer are caused by tobacco smoke. About 90% of patients seeking medical help are found to be directly exposed to it. The most affected cells are the small squamous types. Tobacco contains multiple components however, not all of these may cause lung cancer. It is known that there are only a few that may really trigger the cells to undergo changes. Mazzone (p1) in his study identified N-nitrosamines and polycyclic aromatic hydrocarbons to be the two most carcinogens that are

Compare and contrast music Essay Example | Topics and Well Written Essays - 1000 words

Compare and contrast music - Essay Example This "Compare and contrast music" outlines the comparison of JS Bach’s Brandenburg Concerto 4 (First Movement – Allegro) and Joseph Haydn’s London Symphony (No.104 First Movement). The most obvious difference between the two pieces is their musical style. JS Bach’s music is synonymous with the Baroque style, with a high contrapuntal texture. The parallel melody lines are tightly and finely woven in Bach’s music. This is evident in the first allegro of Brandenburg Concerto 4. The Brandenburg Concertos contain an assortment of pieces with varying styles. Some were courtly dances like the first concerto, whereas some others invoke a poignant romance like the sixth concerto. Concerto 4 is full of zestfulness and vivacity, particularly the Allegro. It contains many of typical features of Bach’s music, namely, precisely constructed harmonies, harmonic progression, polyphony and intricate part writing. The six concertos as a whole were conceived as experimentation in form. Conventionally the concerto forms identified a solo lead instrument and the other instruments were assigned the status of accompaniments. Such an arrangement is mostly evident in the works of two eminent contemporaries of Bach – George Frideric Handel and Antonio Vivaldi. But unlike Handel or Vivaldi, the musical texture of Bach is such that the distinction between ‘main’ and ‘accompanying’ instruments is constantly challenged. This is deduced from the fact that each melody line can exist on its own accord – they stand as perfectly whole compositions. ... But unlike Handel or Vivaldi, the musical texture of Bach is such that the distinction between ‘main’ and ‘accompanying’ instruments is constantly challenged. (Kanny 2013) This is deduced from the fact that each melody line can exist on its own accord – they stand as perfectly whole compositions. When two such melodies were brought to harmony the music takes on an altogether new dimension. To express in common parlance the sum is much greater than the parts. The greatness of Bach lies in the fact that the parts are themselves complete and rich. This is very much the case in the Allegro of Brandenburg Concerto 4. Here, the flute and two Oboes work in counterpoint to the other, producing a rich and finely knit texture. The other feature of the Allegro in Brandenburg Concerto 4 is its beautifully crafted alternations of tempo. Joseph Haydn is the father of the Symphony. He popularized this form and made it his own. His more than 100 Symphonies composed o ver his lifetime stand testimony to this fact. The piece being perused for this comparative analysis is the first movement of his London Symphony (No.104). The instruments for which it is scored include two flutes, two clarinets in A, two bassoons, two horns in D and G. There are also two trumpets in D to go along with timpani and strings. The introduction begins with strings at a slow yet grandiose fashion, alternating between solemn and triumphant moods. Then the only theme of the movement is introduced. The strings play the dominant role in the theme, which is later transposed in A Major to the woodwinds. This is followed by a codetta. Later the theme is developed again with variation. The theme which was first expressed in D